Nucleotide Binding Preference of the Monofunctional Platinum Anticancer-Agent Phenanthriplatin
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چکیده
منابع مشابه
Nucleotide Binding Preference of the Monofunctional Platinum Anticancer-Agent Phenanthriplatin.
The monofunctional platinum anticancer agent phenanthriplatin generates covalent adducts with the purine bases guanine and adenine. Preferential nucleotide binding was investigated by using a polymerase stop assay and linear DNA amplification with a 163-base pair DNA double helix. Similarly to cisplatin, phenanthriplatin forms the majority of adducts at guanosine residues, but significant diffe...
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Monofunctional platinum(II) complexes of general formula cis-[Pt(NH(3))(2)(N-heterocycle)Cl]Cl bind DNA at a single site, inducing little distortion in the double helix. Despite this behavior, these compounds display significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin. To discover the most potent monofunct...
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ژورنال
عنوان ژورنال: Chemistry - A European Journal
سال: 2016
ISSN: 0947-6539
DOI: 10.1002/chem.201600236